How Many Packs of Cigarettes Are in a Vape? Vaping vs Smoking vs IQOS: Which is Least Harmful? The nicotine content of many 2ml nicotine pods for multi pod devices is equivalent to a pack of 20 cigarettes. If you don't smoke, don't vape. And if you are smoking What's the Difference Between E Cigarettes and Vapes? Grow Strong KC Doctor says smoking one vape is equivalent of disturbing amount of cigarettes