E cigarette use and respiratory disorders: an integrative review of converging evidence from epidemiological and laboratory studies European Respiratory Society Heightened response to e cigarettes in COPD Ex Smokers with COPD Susceptible to Harm From Air Pollution RT Vaping and COPD: Is There A Link? In people who had never smoked regular cigarettes, e cigarette use was associated with 75% higher odds of COPD, according to one study.